Amyotrophic lateral sclerosis (ALS) is a devastating, motor neuron degenerative disease without any cure.About 95% of the ALS patients feature abnormalities in the RNA/DNA-binding protein, TDP-43, involving its nucleo-cytoplasmic mislocalization in Glucosamine spinal motor neurons.How TDP-43 pathology triggers neuronal apoptosis remains unclear.In
Abstract F-theory/heterotic duality is formulated in the stable degeneration limit of a K3 fibration on the F-theory side.In this note, we analyze the structure of the stable degeneration limit.We discuss whether stable degeneration exists for pairs of rational elliptic surfaces.We demonstrate that, when two rational elliptic surfaces have an ident
A cross-sectional survey was conducted to determine the relative rankings of 17 key components in an undergraduate program.The degree of discrepancy between curricular content and that of student and pharmacist expectations was also of interest.An online questionnaire was emailed to both groups in one Canadian province.Respondents considered four q
IntroductionRespiratory syncytial virus (RSV) remains a major international public health concern.However, disease treatment is limited to preventive care with monoclonal antibodies and supportive care.In this study, natural products were screened to identify novel anti-RSV inhibitors.MethodsThe antiviral effect of 320 compounds on Double UPH Bench
Precise and robust wind power prediction can effectively alleviate the problem caused by the randomness and volatility of wind power.Ensemble learning can successfully improve forecasting precision Celery and robustness, and quantify the uncertainty of the prediction.This paper presents a new ensemble probabilistic forecasting framework, based on m